Fecha/hora: 20/05/2024 04:25:40

Biblioteca(s): 	INIA La Estanzuela.	
Fecha corriente: 	24/04/2018	
Fecha de la última actualización: 	09/10/2019	
Autoria: 	GIANNITTI, F.; FRAGA, M.; CAFFARENA, D.; SCHILD, C.; BANCHERO, G.; ARMIÉN, A.G.; TRAVERÍA, G.; MARTHALER, D.; WELLS, S.J.; RIET-CORREA, F.	
Afiliación: 	FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay./Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.; MARTIN FRAGA COTELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RUBEN DARÍO CAFFARENA LEDESMA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS SCHILD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANÍBAL GUILLERMO ARMIÉN, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.; GABRIEL TRAVERÍA, Centro de Diagnóstico e Investigaciones Veterinarias (CEDIVE), Universidad Nacional de La Plata, Chascomús, Buenos Aires, Argentina.; DOUGLAS MARTHALER, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.; SCOTT JOSEPH WELLS, Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.	
Título: 	Mycobacterium paratuberculosis sheep type strain in Uruguay: Evidence for a wider geographic distribution in South America.	
Año de publicación: 	2018	
Fuente/Imprenta: 	Journal of Infection in Developing Countries , v. 12, n. 3, p.190-195, 2018.	
DOI: 	10.3855/jidc.9751	
Idioma: 	Inglés	
Notas: 	Article history: Received 11 September 2017 // Accepted 15 March 2018.	
Contenido: 	Abstract:
Johne?s disease (JD) is an economically important disease of ruminants caused by Mycobacterium avium paratuberculosis (MAP), which also
infects other species including humans. Two major MAP strain types are currently recognized: sheep (S) and cattle (C) types. Information on
JD prevalence and MAP types infecting small ruminants in South America is limited, and all but one of the MAP types reported from this
region are of the C type. This study describes clinicopathological, molecular and microbiological findings in 11 cases of JD caused by a type
S MAP strain, and estimated true within-flock prevalence in a ~735-sheep operation in Uruguay. Postmortem examination and histology
(hematoxylin-eosin and Ziehl-Neelsen stains) of samples from 41 selected sheep revealed lymphohistiocytic/granulomatous enteritis and
mesenteric lymphadenitis in 11 animals, with moderate/severe multibacillary lesions in 6 clinical cases, and minimal/mild paucibacillary lesions
in 5 sub-clinical cases. Immunohistochemistry using an antibody against Mycobacterium bovis that cross-reacts with MAP (2 cases), and
transmission electron microscopy (1 case), revealed myriads of intrahistiocytic mycobacteria. MAP was isolated in one case and detected by
PCR in 6 cases. The S type of MAP was identified using a multiplex PCR that distinguishes between S and C types, and PCR-REA. The
estimated true within-flock prevalence was ? 2.3%. This represents the first communication on within-flock prevalence of JD associated with
a type S MAP strain in South America and the second documentation of this strain in the subcontinent. Additional studies are required to better
understand the molecular epidemiology of the different MAP types in the region.	
Palabras-Clave: 	ENTERITIS; INFECTIOUS DISEASE; LIVESTOCK; PARATUBERCULOSIS; PLATAFORMA SALUD ANIMAL; RUMINANTS.	
Thesagro: 	ENFERMEDADES INFECCIOSAS; OVEJA; RUMIANTES; URUGUAY.	
Categoría del tema: 	L73 Enfermedades de los animales	
Registro original: 	INIA La Estanzuela (LE)	
Ejemplares: 	LE - (102384-1) - PXI - AP - DD -  -  -  - DIS